Epstein–Barr virus
How to treat Epstein–Barr virus (EBV)?
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The Epstein–Barr virus (EBV), formally called Human gammaherpesvirus 4, is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus.
Symptoms:
- Enlarged spleen
- Swollen liver
- White patches on tonsils
Palliative care:
- Get plenty of rest
- Drink lots of water
- Gargle with salt water
- Take painkillers like acetaminophen or ibuprofen to bring down fever and relieve body aches.
- Avoid heavy lifting to prevent spleen injury.
Other diseases caused by EBV: - Ear infections - Guillain-Barre syndrome - Cancers, like Burkitt's lymphoma and cancers of the nose and throat
The genome of EBV:
- NCBI - Human gammaherpesvirus 4, complete genome (can use GBench to open, for example, exporting as FASTA file)
The coded proteins of EBV:
EBNA-1 (lytic) - EBNA-2 (lytic) - EBNA-3 (lytic) - LMP-1 - LMP-2 - EBER - v-snoRNA1 - ebv-sisRNA - miRNAs - EBV-EA (lytic) - EBV-MA (lytic) - EBV-VCA (lytic) - EBV-AN (lytic).
Reactivation and therapeutic inhibitors
Epstein-Barr virus (EBV) reactivation and therapeutic inhibitor [2019]
[DRUG] According to Swaminathan lab and others previously showed that SM protein is essential for EBV replication. About effects: spironolactone (youtube).
[STRATEGY]: Get to know, how EBV causes nasopharyngeal carcinoma, Hodgkin's lymphoma and Burkitt's lymphoma, and take preventative measures.
- Sulforaphane (SFN) was found to be effective in the inhibition of EBV reactivation in latent EBV-positive NPC cells -- https://pubmed.ncbi.nlm.nih.gov/22641235/.
[STRATEGY] EBV can be almost completely cleared from latently infected EBV-transformed human tumor cells, using CRISPR/Cas9 system to effectively target herpesvirus genomes as a potent prophylactic and therapeutic anti-viral strategy to impair viral replication and clear latent virus infection.
